I did a Miami to Chicago run and wanted to see how much mpg I coul get, and have the fewest possible stops. This was a 1400 mile distance.
Managed to get 28 mpg mostly cruising 75-85.
Stop 1 was in Gainesville,, FL (~300 mi)
Stop 2 was near Macon, GA (~ 250 mi)
Stop 3 was in Nashville, TN (~ 330 mi)
Stop 4 was somewhere near Louisville, KY (~ 175)
At that point I had enough gas to get to Chicago, (~ 300 mi more) would have made it but had to make one more stop just because I was tired as hell.
About 300-333 miles between each stop! I didn't know my car could do more than 200 miles on a tank